Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 16/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19569638 | 1.00 | ATF4 (0.48) | ATF4SMYD3KDM4EPOLBHTT | |
| SCHEMBL30961489 | 0.93 | ATF4 (0.51) | ATF4KDM4E | |
| SCHEMBL20999735 | 0.93 | ATF4 (0.51) | ATF4KDM4E | |
| SCHEMBL19569546 | 0.93 | ATF4 (0.51) | ATF4KDM4E | |
| SCHEMBL22396728 | 0.91 | ATF4 (0.50) | ATF4 | |
| SCHEMBL19569334 | 0.91 | ATF4 (0.50) | ATF4 | |
| SCHEMBL30025996 | 0.91 | ATF4 (0.50) | ATF4 | |
| SCHEMBL22396848 | 0.90 | ATF4 (0.49) | ATF4 | |
| SCHEMBL19569647 | 0.90 | ATF4 (0.49) | ATF4 | |
| SCHEMBL22396700 | 0.89 | ATF4 (0.53) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704094-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |