Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.44 |
| ▸ | PDE4A | P27815 | 6/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30421897 | 1.00 | ALOX15 (0.56) | ALOX15PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30421034 | 1.00 | ALOX15 (0.56) | ALOX15PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL30421104 | 0.90 | ALOX15 (0.61) | ALOX15GRM5POLB | |
| SCHEMBL22392805 | 0.84 | EGFR (0.45) | ALOX15PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL22392856 | 0.84 | EGFR (0.45) | ALOX15PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL22392807 | 0.84 | EGFR (0.45) | ALOX15PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL29469533 | 0.78 | ALOX15 (0.59) | ALOX15POLB | |
| SCHEMBL30420987 | 0.77 | ALOX15 (0.58) | ALOX15POLB | |
| SCHEMBL1201785 | 0.76 | GRM5 (0.50) | GRM5 | |
| SCHEMBL6818987 | 0.75 | NPC1 (0.47) | ALOX15PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704112-A1 | ALKENE SPIROCYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS | Bristol-Myers Squibb Company (US) | 2020-09-09 | — | — | EP | disclosed |