Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941489 | 1.00 | HSD17B10 (0.51) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL30179824 | 1.00 | HSD17B10 (0.51) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL4082700 | 1.00 | HSD17B10 (0.51) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| Phenol SCHEMBL29155438 | 0.91 | KMT2A (0.46) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL16213357 | 0.79 | PARP1 (0.50) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL22011499 | 0.78 | GSK3B (0.46) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL8163254 | 0.75 | HSD17B10 (0.61) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL18215410 | 0.75 | HSD17B10 (0.61) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL22268104 | 0.74 | HTR2A (0.35) | HSD17B10HTR2AHTR2CHTR2BPARP1 | |
| SCHEMBL19573960 | 0.74 | TNKS2 (0.49) | HSD17B10HTR2AHTR2CHTR2BPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704091-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |