Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 5/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31492881 | 0.92 | IDO1 (0.90) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL22397378 | 0.92 | IDO1 (0.90) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL22397379 | 0.89 | IDO1 (1.00) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL31492922 | 0.86 | IDO1 (0.72) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL22397381 | 0.86 | IDO1 (0.72) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL23520113 | 0.86 | IDO1 (0.71) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL25780435 | 0.85 | IDO1 (0.90) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL22397554 | 0.85 | IDO1 (0.70) | IDO1KCNH2LMNATP53HDAC1 | |
| SCHEMBL22397560 | 0.85 | IDO1 (0.72) | IDO1KCNH2LMNATP53THRB | |
| SCHEMBL22397373 | 0.85 | IDO1 (0.72) | IDO1KCNH2LMNATP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179607-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-17 | — | — | US | disclosed |
| EP-3703692-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2020-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179607-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | IDO1, IDO2, KYNU | IDO1 1/4885KCNH2 3836/4885LMNA 4652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.