KYNU

Kynureninase · Q16719 · KYNU on Sugi Atlas →

5,418 patent compounds predicted against KYNU, 3,440 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL975884	0.42	3/20
SCHEMBL1972988	0.53	2/20
SCHEMBL635315	0.53	2/20
SCHEMBL231473	0.51	2/20
SCHEMBL288377	0.51	2/20
SCHEMBL288832	0.51	2/20
SCHEMBL385780	0.51	2/20
Phenylalanine (SCHEMBL1507755)	0.51	2/20
SCHEMBL2929863	0.51	2/20
Kynurenine (SCHEMBL3349840)	0.51	2/20
L-Kynurenine (SCHEMBL3349843)	0.51	2/20
SCHEMBL1984486	0.50	2/20
SCHEMBL1984487	0.50	2/20
Kynurenine (SCHEMBL20874)	0.49	2/20
L-Kynurenine (SCHEMBL20875)	0.49	2/20
Kynurenine (SCHEMBL288254)	0.49	2/20
Kynurenine (SCHEMBL288988)	0.49	2/20
L-Kynurenine (SCHEMBL288989)	0.49	2/20
SCHEMBL1519953	0.49	2/20
Kynurenine (SCHEMBL2181581)	0.49	2/20

Clinical trials — most relevant to KYNU by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Kuvan on Melatonin Secretion	PHASE4	COMPLETED
Tryptophan MRI in People With Schizophrenia and Healthy Controls	PHASE2/PHASE3	COMPLETED
Ketamine's Efficiency in the Treatment of Chronic Pain: Kynurenin Pathway	PHASE3	UNKNOWN
The Effects of Kynurenine Aminotransferase Inhibition in People With Schizophrenia	PHASE1/PHASE2	COMPLETED
A Study to Evaluate KYN-5356 in Adults With Cognitive Impairment Associated With Schizophrenia	PHASE2	RECRUITING
Leucine in Midlife Depression	PHASE2	RECRUITING
Safety and Efficacy Study of Phenoptin in Subjects With Hyperphenylalaninemia Due to BH4 Deficiency	PHASE2	COMPLETED
Diclofenac Dose Response Study	PHASE1	RECRUITING
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine	EARLY_PHASE1	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
Tryptophan-Kynurenine Pathway Metabolism in the Pathophysiology of Cognitive Impairment in Schizophrenia.	nan	ENROLLING_BY_INVITATION
Tryptophan Metabolism in Healthy Young Adults	nan	COMPLETED
A Longitudinal Study of Inflammatory Pathways in Depression	nan	COMPLETED
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes	nan	NOT_YET_RECRUITING
Effect of Genetic Alterations Affecting the Genes Encoding the Major Enzymes of the Kynurenine Pathway on Suicidal Behavior	nan	COMPLETED
Role of Inflammation in Psychiatric Disorders in Patients With Cutaneous Lupus	nan	COMPLETED
An Assessment of Cognitive Function in Irritable Bowel Syndrome	nan	UNKNOWN
Obesity and Obesity-Related Factors and Risk of Herpes Zoster (Shingles) and Postherpetic Neuralgia	nan	ACTIVE_NOT_RECRUITING
Effect of Omega-3 Fatty Acids on Kynurenine Metabolism and Mood	nan	UNKNOWN
Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults	nan	COMPLETED
Assesment of Vitamin B6 Level in Patients With Major Depressive Disorder	nan	UNKNOWN
Biological Triggers of Depression in Pregnancy	nan	COMPLETED
Disturbances of Kynurenine Pathway of Trytophan Metabolism in Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study	nan	COMPLETED
Blood Biomarkers in Electroconvulsive Therapy	nan	ENROLLING_BY_INVITATION
Examining the Link Between Depression and Seasonal Allergies	nan	COMPLETED
Evaluation of the Relationship Between Bruxism and Tryptophan Metabolites	nan	COMPLETED
Tryptophan Metabolism in Human Brain Tumors	nan	COMPLETED
Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Inflammation and Depression Following SCI	nan	RECRUITING
Metabolomic Evaluation of Psycho-surgical Synergy on Body Image Restoration After Breast Cancer	nan	RECRUITING
Biomarkers as Predictors of Suicidal Risk in Adolescents	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KYNU binder may also engage these)

Protein	Name	Similarity
P70712	—	1.000	P70712 →
Q9CXF0	—	0.992	Q9CXF0 →
A8XKT0	—	0.983	A8XKT0 →
A7SCH8	—	0.981	A7SCH8 →
Q18026	—	0.980	Q18026 →
A1CWY1	—	0.979	A1CWY1 →
Q2U038	—	0.978	Q2U038 →
Q1DZA6	—	0.977	Q1DZA6 →
SGPL1	Sphingosine-1-phosphate lyase 1	0.976	landscape →
Q0CZX6	—	0.976	Q0CZX6 →
Q0CPB0	—	0.976	Q0CPB0 →
Q8R0X7	—	0.976	Q8R0X7 →
A1DGW4	—	0.975	A1DGW4 →
DDC	Aromatic-L-amino-acid decarboxylase	0.975	landscape →
Q4X1D4	—	0.975	Q4X1D4 →
Q8RY79	—	0.974	Q8RY79 →
Q7RXY2	—	0.974	Q7RXY2 →
A5DM91	—	0.973	A5DM91 →
Q4WPN0	—	0.973	Q4WPN0 →
PSAT1	Phosphoserine aminotransferase	0.973	landscape →
A6RSP5	—	0.973	A6RSP5 →
A0A565D475	—	0.973	A0A565D475 →
A6H1P7	—	0.973	A6H1P7 →
Q94IB8	—	0.973	Q94IB8 →
B0XS72	—	0.973	B0XS72 →
A7TR79	—	0.972	A7TR79 →
A1C688	—	0.972	A1C688 →
Q6K8E7	—	0.972	Q6K8E7 →
Q5R4G0	—	0.972	Q5R4G0 →
O88533	—	0.972	O88533 →