Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 19/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL31492866 | 0.95 | IDO1 (0.50) | IDO1MAPK8KCNH2 | |
| SCHEMBL23520259 | 0.84 | IDO1 (0.41) | IDO1MAPK8 | |
| SCHEMBL22397733 | 0.77 | IDO1 (0.42) | IDO1 | |
| SCHEMBL32666196 | 0.75 | IDO1 (0.74) | IDO1MAPK8KCNH2 | |
| SCHEMBL24138179 | 0.75 | IDO1 (0.74) | IDO1MAPK8KCNH2 | |
| SCHEMBL24138180 | 0.75 | IDO1 (0.74) | IDO1MAPK8KCNH2 | |
| SCHEMBL23795500 | 0.75 | IDO1 (0.75) | IDO1MAPK8KCNH2 | |
| SCHEMBL22397355 | 0.71 | IDO1 (0.87) | IDO1KCNH2 | |
| SCHEMBL22397646 | 0.71 | ROCK1 (0.47) | IDO1 | |
| SCHEMBL24138209 | 0.70 | IDO1 (1.00) | IDO1MAPK8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179607-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-06-17 | — | — | US | disclosed |
| EP-3703692-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2020-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210179607-A1 | NOVEL SUBSTITUTED TETRAHYDROQUINOLIN COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | IDO1, IDO2, KYNU | IDO1 1/4885MAPK8 2299/4885KCNH2 3836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.