Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.50 |
| ▸ | PIM1 | P11309 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | PRKACA | P17612 | 4/20 | 0.50 |
| ▸ | KDR | P35968 | 4/20 | 0.50 |
| ▸ | GSK3A | P49840 | 4/20 | 0.50 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.50 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.50 |
| ▸ | CLK2 | P49760 | 4/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29742282 | 0.84 | BCL2L1 (0.59) | DYRK1ADYRK1BDAPK3PIM1KDR | |
| SCHEMBL2897390 | 0.84 | BCL2L1 (0.59) | DYRK1ADYRK1BDAPK3PIM1KDR | |
| SCHEMBL17988510 | 0.82 | CLK1 (0.67) | DYRK1ADYRK1BCLK2CLK4MEN1 | |
| SCHEMBL19756728 | 0.82 | MEN1 (0.49) | DYRK1ADYRK1BCLK2CLK4MEN1 | |
| Hydrochloric Acid SCHEMBL9432267 | 0.81 | F9 (0.60) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL312215 | 0.80 | DYRK1A (0.51) | DYRK1ADYRK1BDAPK3PIM1FGFR1 | |
| SCHEMBL7075713 | 0.80 | DYRK1A (0.69) | DYRK1ADYRK1BDAPK3PIM1FGFR1 | |
| Hydrochloric Acid SCHEMBL9432537 | 0.79 | F9 (0.59) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3402922 | 0.79 | DYRK1A (0.50) | DYRK1ADYRK1BDAPK3PIM1FGFR1 | |
| SCHEMBL4745481 | 0.79 | DYRK1A (0.50) | DYRK1ADYRK1BDAPK3PIM1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12286426-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2025-04-29 | — | — | US | disclosed |
| EP-3704111-B1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2024-10-09 | — | — | EP | disclosed |
| CN-111886234-B | Heterocyclic mitochondrial activity inhibitors and uses thereof | 蒙特利尔大学 | 2023-12-15 | — | — | CN | disclosed |
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | Université de Montréal (CA) | 2021-12-16 | — | — | US | disclosed |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | Université de Montréal (CA) | 2021-12-16 | — | — | US | disclosed |
| CN-111886234-A | Heterocyclic mitochondrial activity inhibitors and uses thereof | 蒙特利尔大学 | 2020-11-03 | — | — | CN | disclosed |
| EP-3704111-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | Université de Montréal (CA) | 2020-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, IDH1 | DYRK1A 2621/4885DYRK1B 2240/4885DAPK3 1633/4885 |
| US-12286426-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | IDH2, TFAM, IDH1 | DYRK1A 2621/4885DYRK1B 2240/4885DAPK3 1633/4885 |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, NUTF2 | DYRK1A 2725/4885DYRK1B 2428/4885DAPK3 1552/4885 |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | IDH2, TFAM, NUTF2 | DYRK1A 2725/4885DYRK1B 2428/4885DAPK3 1552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.