Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.73 |
| ▸ | GAA | P10253 | 4/20 | 0.73 |
| ▸ | CDC25A | P30304 | 1/20 | 0.67 |
| ▸ | CDC25B | P30305 | 1/20 | 0.67 |
| ▸ | BACE1 | P56817 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | DUSP26 | Q9BV47 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | TTR | P02766 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1789288 | 0.94 | CDC25A (0.75) | MAPTGAACDC25ACDC25BBACE1 | |
| SCHEMBL3135247 | 0.90 | MAPT (0.70) | MAPTCDC25ACDC25BBACE1TP53 | |
| SCHEMBL1793147 | 0.90 | MAPT (0.76) | MAPTGAAPOLBALDH1A1MEN1 | |
| SCHEMBL1790930 | 0.90 | CDC25A (0.77) | MAPTGAACDC25ACDC25BBACE1 | |
| SCHEMBL14050702 | 0.88 | CDC25A (0.67) | MAPTGAACDC25ACDC25BBACE1 | |
| SCHEMBL1793225 | 0.88 | MAPT (0.71) | MAPTGAACDC25ACDC25BBACE1 | |
| SCHEMBL1793277 | 0.88 | MAPT (0.77) | MAPTGAAPOLBALDH1A1MEN1 | |
| SCHEMBL1789256 | 0.88 | TTR (0.73) | MAPTGAACDC25ACDC25BBACE1 | |
| SCHEMBL1790988 | 0.88 | TTR (0.73) | MAPTGAACDC25ACDC25BBACE1 | |
| SCHEMBL1788293 | 0.88 | MEN1 (0.68) | MAPTGAACDC25ACDC25BBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128388-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140128388-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-05-08 | — | — | US | disclosed |
| US-20140128388-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-05-08 | — | — | US | disclosed |
| US-8541415-B2 | Targeting an HIV-1 nef-host cell kinase complex | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541415-B2 | Targeting an HIV-1 nef-host cell kinase complex | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541415-B2 | Targeting an HIV-1 nef-host cell kinase complex | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2013-09-24 | — | — | US | disclosed |
| US-20110190241-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERISTY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-08-04 | — | — | US | disclosed |
| US-20110190241-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERISTY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-08-04 | — | — | US | disclosed |
| US-20110190241-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERISTY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-08-04 | — | — | US | disclosed |
| WO-2009139886-A2 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190241-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | HCK, DCK, NCK1 | MAPT 1585/4885GAA 4434/4885CDC25A 346/4885 |
| US-20140128388-A1 | TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEX | HCK, DCK, NCK1 | MAPT 1549/4885GAA 4424/4885CDC25A 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.