Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 5/20 | 0.41 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23456278 | 1.00 | NAE1 (0.41) | NAE1UBA3TYMPACP1CYP3A4 | |
| SCHEMBL23456015 | 0.92 | TYMP (0.37) | NAE1UBA3TYMPACP1CYP3A4 | |
| SCHEMBL30960563 | 0.87 | TYMP (0.36) | NAE1UBA3TYMPACP1CYP3A4 | |
| SCHEMBL23456122 | 0.87 | TYMP (0.36) | NAE1UBA3TYMPACP1CYP3A4 | |
| SCHEMBL23456031 | 0.87 | TYMP (0.36) | NAE1UBA3TYMPACP1CYP3A4 | |
| SCHEMBL22401404 | 0.85 | ACP1 (0.39) | NAE1UBA3TYMPACP1CYP3A4 | |
| SCHEMBL23456067 | 0.85 | ACP1 (0.39) | NAE1UBA3TYMPACP1CYP3A4 | |
| SCHEMBL23456102 | 0.82 | SLC6A1 (0.33) | TYMPACP1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL23455991 | 0.80 | TYMP (0.37) | NAE1UBA3TYMPIRAK4SLC6A1 | |
| SCHEMBL23456114 | 0.78 | NAE1 (0.37) | NAE1UBA3TYMPHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3707151-A1 | STING MODULATOR COMPOUNDS, AND METHODS OF MAKING AND USING | Takeda Pharmaceutical Company Limited (JP) | 2020-09-16 | — | — | EP | disclosed |