Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.49 |
| ▸ | NAAA | Q02083 | 2/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28430051 | 0.77 | NAAA (0.58) | MEN1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL12883043 | 0.76 | MAPT (0.82) | MAPTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL7908917 | 0.75 | NOTUM (0.62) | MAPTTSHRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL30539320 | 0.75 | NOTUM (0.62) | MAPTTSHRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL794035 | 0.74 | MAPT (0.47) | MAPTMEN1KMT2ATSHRLMNA | |
| SCHEMBL9057075 | 0.74 | ASAH1 (0.61) | HDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL21246047 | 0.73 | TSHR (0.81) | MAPTMEN1KMT2ATSHRLMNA | |
| SCHEMBL4552575 | 0.73 | DRD3 (0.60) | — | |
| SCHEMBL794614 | 0.73 | MAPT (0.46) | MAPTMEN1KMT2ATSHRLMNA | |
| SCHEMBL3748990 | 0.73 | MAPT (0.62) | MAPTMEN1KMT2ATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3706747-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2020-09-16 | — | — | EP | disclosed |