Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | ABL2 | P42684 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27825171 | 0.81 | BRD4 (0.46) | ALDH1A1HPGDBRD4SMN1; SMN2MAPT | |
| SCHEMBL20878376 | 0.80 | BRD4 (0.56) | ALDH1A1HPGDBRD4SMN1; SMN2MAPT | |
| SCHEMBL27843972 | 0.77 | HPRT1 (0.44) | ALDH1A1HPGDMAPK1HSD17B10BRD4 | |
| SCHEMBL7918743 | 0.76 | MAPT (0.56) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL27917128 | 0.76 | CYP1A2 (0.60) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL1227713 | 0.76 | CYP1A2 (0.60) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL29699887 | 0.76 | CYP1A2 (0.60) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL25149668 | 0.76 | BRD4 (0.45) | ALDH1A1HPGDACVR1BRD4SMN1; SMN2 | |
| SCHEMBL30487734 | 0.74 | CYP1A2 (0.58) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL28021254 | 0.74 | BCHE (0.48) | ALDH1A1HPGDKDM4EMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283403-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Valo Health, LLC | 2020-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283403-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, HAMP, NQO1 | NPC1 459/4885RAB9A 1352/4885ALDH1A1 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.