Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 9/20 | 0.86 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.86 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20770893 | 0.93 | ENPP1 (1.00) | ENPP1ENPP3TLR8WNT3AHTR1A | |
| SCHEMBL30105952 | 0.93 | ENPP1 (1.00) | ENPP1ENPP3TLR8WNT3AHTR1A | |
| SCHEMBL22407357 | 0.85 | ENPP1 (0.66) | ENPP1ENPP3TLR8HTR1AADRA1D | |
| SCHEMBL22407465 | 0.84 | ENPP1 (0.80) | ENPP1ENPP3TLR8WNT3AHTR1A | |
| SCHEMBL22407404 | 0.84 | ENPP3 (0.61) | ENPP1ENPP3TLR8WNT3AHTR1A | |
| SCHEMBL22435914 | 0.83 | ENPP1 (0.76) | ENPP1ENPP3TLR8WNT3AGRM4 | |
| SCHEMBL22407348 | 0.82 | ENPP1 (0.80) | ENPP1ENPP3TLR8WNT3AHTR1A | |
| SCHEMBL24009119 | 0.81 | ENPP1 (0.78) | ENPP1ENPP3TLR8WNT3AHTR1A | |
| SCHEMBL22407333 | 0.81 | ENPP1 (0.74) | ENPP1ENPP3CA12CA1CA2 | |
| SCHEMBL20782860 | 0.80 | ENPP1 (0.71) | ENPP1ENPP3GRM4FERMT2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ABBVIE INC (US) | 2023-06-15 | — | — | US | disclosed |
| US-20200291024-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ABBVIE INC (US) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291024-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, STING1 | ENPP1 1/4885ENPP3 2/4885TLR8 1420/4885 |
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, STING1 | ENPP1 1/4885ENPP3 2/4885TLR8 1420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.