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Sugi Predict / Targets / ENPP3

ENPP3

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 · O14638 · ENPP3 on Sugi Atlas →

22,402 patent compounds predicted against ENPP3, 10,635 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1240947 SCHEMBL1240947 0.65 9/20
SCHEMBL713850 SCHEMBL713850 0.63 9/20
SCHEMBL713991 SCHEMBL713991 0.63 8/20
SCHEMBL581728 SCHEMBL581728 0.49 8/20
Dihydralazine Dihydralazine (SCHEMBL1374523) 0.41 8/20
SCHEMBL1439001 SCHEMBL1439001 0.87 7/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1438899) 0.85 7/20
SCHEMBL509734 SCHEMBL509734 0.52 7/20
SCHEMBL1358542 SCHEMBL1358542 0.51 7/20
SCHEMBL581369 SCHEMBL581369 0.49 7/20
SCHEMBL201523 SCHEMBL201523 0.96 6/20
SCHEMBL496875 SCHEMBL496875 0.64 6/20
SCHEMBL711139 SCHEMBL711139 0.60 6/20
SCHEMBL1384116 SCHEMBL1384116 0.58 6/20
SCHEMBL753657 SCHEMBL753657 0.56 6/20
SCHEMBL1384115 SCHEMBL1384115 0.56 6/20
SCHEMBL1225671 SCHEMBL1225671 0.54 6/20
SCHEMBL1200604 SCHEMBL1200604 0.54 6/20
SCHEMBL708780 SCHEMBL708780 0.54 6/20
SCHEMBL580484 SCHEMBL580484 0.45 6/20

Clinical trials — most relevant to ENPP3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
The ENERGY 3 Study: Evaluation of Efficacy and Safety of INZ-701 in Children With ENPP1 Deficiency PHASE3ACTIVE_NOT_RECRUITING
Evaluation of Safety, Tolerability, and Efficacy of INZ-701 in Adults With ENPP1 Deficiency PHASE1/PHASE2COMPLETED
Safety and Efficacy Study of ENB-0040 in Juvenile Patients With Hypophosphatasia (HPP) PHASE2WITHDRAWN
A Study of ES002023 (Anti-CD39 Antibody) in Patients With Locally Advanced or Metastatic Solid Tumors PHASE1COMPLETED
The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency PHASE1RECRUITING
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Foci of Tumor Heterogeneity in Diffuse Low-Grade Gliomas nanCOMPLETED
Natural History of GACI With or Without ARHR2 or PXE nanUNKNOWN
Study of People With Generalized Arterial Calcification of Infancy (GACI) or Autosomal Recessive Hypophosphatemic Rickets Type 2 (ARHR2) nanCOMPLETED
Exome Sequencing for Atypical Femoral Fractures nanCOMPLETED
PROPEL - A Prospective Observational Patient Registry to Evaluate ENPP1 and ABCC6 Deficiency nanRECRUITING
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism nanNOT_YET_RECRUITING
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics) nanCOMPLETED
Studying Phosphorus Metabolism nanCOMPLETED
Biomarker for Hypophosphatasia Disease (BioHypophos) nanWITHDRAWN
Pathophysiology of Paget's Disease of Bone nanCOMPLETED
Genetic Studies of Lysosomal Storage Disorders nanENROLLING_BY_INVITATION
Molecular and Clinical Studies of Primary Immunodeficiency Diseases nanUNKNOWN
Natural History Study of ENPP1 Deficiency and the Early-onset Form of ABCC6 Deficiency nanCOMPLETED
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte nanCOMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases nanUNKNOWN
Phenotype/Genotype Correlations in Neuromuscular Disorders nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Understanding the Spectrum of ENPP1 Deficiency and Acute ABCC6 Deficiency nanCOMPLETED
PCD New Gene Discovery nanCOMPLETED
Genetic Studies of Inflammatory Bowel Disease nanCOMPLETED
Study of the Pathophysiological Mechanisms Involved in Bleeding Events nanCOMPLETED
Epilepsy Phenome/Genome Project nanCOMPLETED
Genetics and Psychopathology in the 22q11 Deletion Syndrome nanUNKNOWN
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a ENPP3 binder may also engage these)

ProteinNameSimilarity
Q5R5M5 — 1.000 Q5R5M5 →
Q6DYE8 — 1.000 Q6DYE8 →
P97675 — 1.000 P97675 →
ENPP1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 0.999 landscape →
W8E7D1 — 0.999 W8E7D1 →
P15396 — 0.998 P15396 →
P0DQQ4 — 0.996 P0DQQ4 →
J3SBP3 — 0.995 J3SBP3 →
J3SEZ3 — 0.995 J3SEZ3 →
P06802 — 0.993 P06802 →
Q924C3 — 0.993 Q924C3 →
A0A2D0TC04 — 0.992 A0A2D0TC04 →
Q9R1E6 — 0.984 Q9R1E6 →
Q64610 — 0.984 Q64610 →
A1A4K5 — 0.981 A1A4K5 →
ENPP2 Autotaxin 0.981 landscape →
Q9NY28 — 0.979 Q9NY28 →
O95498 — 0.978 O95498 →
Q6AYF4 — 0.977 Q6AYF4 →
P18563 — 0.977 P18563 →
Q8R4K8 — 0.976 Q8R4K8 →
Q1RPR6 — 0.976 Q1RPR6 →
Q8K1B9 — 0.976 Q8K1B9 →
Q9D7Z6 — 0.976 Q9D7Z6 →
Q6DDW2 — 0.975 Q6DDW2 →
Q5NDE7 — 0.975 Q5NDE7 →
Q14CN2 — 0.975 Q14CN2 →
Q5RB89 — 0.975 Q5RB89 →
Q29444 — 0.975 Q29444 →
Q8K2I4 — 0.975 Q8K2I4 →