Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 18/20 | 0.89 |
| ▸ | BCL2 | P10415 | 15/20 | 0.89 |
| ▸ | BAD | Q92934 | 4/20 | 0.89 |
| ▸ | BCL2L2 | Q92843 | 2/20 | 0.89 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.89 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.89 |
| ▸ | ASPH | Q12797 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19014632 | 1.00 | BCL2L1 (0.89) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19014705 | 0.96 | BCL2L1 (0.89) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19014891 | 0.95 | BCL2L1 (0.88) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL22409409 | 0.95 | BCL2L1 (0.81) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19145093 | 0.95 | BCL2L1 (0.93) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19145101 | 0.95 | BCL2L1 (0.93) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19014877 | 0.95 | BCL2L1 (0.87) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| SCHEMBL19503523 | 0.94 | BCL2L1 (0.92) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| Navitoclax SCHEMBL10316178 | 0.94 | BCL2L1 (1.00) | BCL2L1BCL2BADBCL2L2BCL2L11 | |
| Navitoclax SCHEMBL15005512 | 0.94 | BCL2L1 (1.00) | BCL2L1BCL2BADBCL2L2BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11111259-B2 | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders | UNITY BIOTECHNOLOGY, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-20200291050-A1 | ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS | UNITY BIOTECHNOLOGY, INC. | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11111259-B2 | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders | ACAT1, ARSA, GLA | BCL2L1 3463/4885BCL2 3060/4885BAD 3436/4885 |
| US-20200291050-A1 | ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS | ACAT1, ARSA, GLA | BCL2L1 3463/4885BCL2 3060/4885BAD 3436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.