ACAT1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3543730	0.85	2/20
SCHEMBL3540446	0.75	2/20
SCHEMBL3537691	0.73	2/20
SCHEMBL3538664	0.72	2/20
Hydrochloric Acid (SCHEMBL3542779)	0.71	2/20
SCHEMBL3544949	0.71	2/20
SCHEMBL3539788	0.67	2/20
SCHEMBL3544471	0.67	2/20
SCHEMBL3542755	0.66	2/20
SCHEMBL3539496	0.66	2/20
SCHEMBL1588111	0.65	2/20
SCHEMBL1588113	0.65	2/20
SCHEMBL3542519	0.65	2/20
SCHEMBL3539813	0.63	2/20
SCHEMBL3545013	0.63	2/20
SCHEMBL3539716	0.62	2/20
SCHEMBL3543207	0.61	2/20
SCHEMBL3544077	0.61	2/20
SCHEMBL1588791	0.61	2/20
SCHEMBL1588796	0.61	2/20

Clinical trials — most relevant to ACAT1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Omega 3 and Ischemic Stroke; Fish Oil as an Option	PHASE4	UNKNOWN
CoQ10 and Exercise for Mitochondrial Dysfunction in Advance Kidney Disease	PHASE3	RECRUITING
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
Overcoming Primary Resistance to Immunotherapy in Metastatic Melanoma	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease	PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC	PHASE1/PHASE2	UNKNOWN
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis	PHASE2	UNKNOWN
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension	PHASE2	NOT_YET_RECRUITING
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With a Novel Form of Anaplerosis	PHASE2	COMPLETED
Effect of Bezafibrate on Muscle Metabolism in Patients With Fatty Acid Oxidation Defects	PHASE2	COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers	PHASE1	COMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Markers of Carnitine Acetyltransferase (CrAT) Protein Activity and Carnitine Availability	nan	COMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP)	nan	COMPLETED
MOLECULAR REGULATION OF MUSCLE GLUCOSE METABOLISM (AIMS 2A, 2B, 3)	nan	UNKNOWN
11C-Acetate PET/CT Non-FDG-Avid Tumors	nan	UNKNOWN
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children	nan	WITHDRAWN
High Fat Diet for Cardiac Metabolic Reprogramming	nan	RECRUITING
A Prospective Study of the Disease Characteristics of Adult Patients With Long Chain Fatty Acid Oxidation Disorders	nan	COMPLETED
Effects of Parenteral L-carnitine Supplementation in Premature Neonates	nan	COMPLETED
Hepatic Energy Fluxes in NASH and NAS Patients	nan	ACTIVE_NOT_RECRUITING
KETO-TUMOR: a Study on Brain Tumors and Central Obesity	nan	RECRUITING
Epidemiology of Atherosclerosis	nan	COMPLETED
Effect of Cocoa Polyphenols Supplementation on Cardiovascular Risk of Postmenopausal Women	nan	UNKNOWN
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Systemic Biomarkers of Brain Injury From Hyperammonemia	nan	RECRUITING
Combining Gene Variants to Improve Risk Prediction for Metabolic (Dysfunction)- Associated Fatty Liver Disease and Its Progression to Cirrhosis in Indian Individuals With Type 2 Diabetes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ACAT1 binder may also engage these)

Protein	Name	Similarity
Q8HXY6	—	1.000	Q8HXY6 →
Q5BKN8	—	0.988	Q5BKN8 →
Q29RZ0	—	0.988	Q29RZ0 →
P17764	—	0.986	P17764 →
Q6AZA0	—	0.985	Q6AZA0 →
Q8QZT1	—	0.985	Q8QZT1 →
Q6NU46	—	0.984	Q6NU46 →
Q6GN02	—	0.979	Q6GN02 →
B0XMC1	—	0.948	B0XMC1 →
Q4WLA8	—	0.948	Q4WLA8 →
I1RMA2	—	0.945	I1RMA2 →
P24226	—	0.937	P24226 →
P36871	—	0.936	P36871 →
Q9C9P4	—	0.935	Q9C9P4 →
Q9D4D4	—	0.935	Q9D4D4 →
Q5R691	—	0.935	Q5R691 →
P49724	—	0.934	P49724 →
Q6B855	—	0.934	Q6B855 →
Q4R5E4	—	0.934	Q4R5E4 →
P00949	—	0.933	P00949 →
P00504	—	0.933	P00504 →
P13086	—	0.933	P13086 →
Q9VW26	—	0.933	Q9VW26 →
Q08DP0	—	0.933	Q08DP0 →
Q29554	—	0.933	Q29554 →
GOT1	Aspartate aminotransferase, cytoplasmic	0.932	landscape →
Q6ZL94	—	0.932	Q6ZL94 →
TKT	Transketolase	0.932	landscape →
Q8GTQ9	—	0.932	Q8GTQ9 →
HADHA	Trifunctional enzyme subunit alpha, mitochondrial	0.932	landscape →