Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SPR | P35270 | 6/20 | 0.44 |
| ▸ | TNKS | O95271 | 7/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410619 | 0.81 | ADORA2A (0.55) | ADORA2AADORA1HPGDSPRTNKS | |
| SCHEMBL22410613 | 0.80 | ADORA2A (0.54) | ADORA2AADORA1HPGDSPRTNKS | |
| SCHEMBL22410955 | 0.80 | ADORA2A (0.54) | ADORA2AADORA1HPGDSPRTNKS | |
| SCHEMBL22410647 | 0.80 | MAPK1 (0.52) | ADORA2AADORA1HPGDTNKSTNKS2 | |
| SCHEMBL22410646 | 0.80 | ADORA2A (0.52) | ADORA2AADORA1HPGDMGLLALDH1A1 | |
| SCHEMBL22410700 | 0.79 | MAPK1 (0.51) | ADORA2AADORA1HPGDTNKSTNKS2 | |
| SCHEMBL22410636 | 0.77 | ADORA2A (0.56) | ADORA2AADORA1HPGDSPRTNKS | |
| SCHEMBL22410759 | 0.77 | ADORA2A (0.55) | ADORA2AADORA1HPGDSPRTNKS | |
| SCHEMBL22410881 | 0.77 | ADORA2A (0.55) | ADORA2AADORA1HPGDSPRTNKS | |
| SCHEMBL22410661 | 0.77 | ADORA2A (0.55) | ADORA2AADORA1HPGDSPRTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3938362-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-01-19 | — | — | EP | claimed |
| WO-2020182990-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-17 | — | — | WO | claimed |