Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 2/20 | 0.48 |
| ▸ | TNKS | O95271 | 5/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22410647 | 0.99 | MAPK1 (0.52) | MAPK1ADORA2AADORA1MGLLTNKS | |
| SCHEMBL22410646 | 0.80 | ADORA2A (0.52) | ADORA2AADORA1MGLLNPC1HPGD | |
| SCHEMBL22410635 | 0.79 | ADORA2A (0.57) | ADORA2AADORA1MGLLTNKSTNKS2 | |
| SCHEMBL22410820 | 0.77 | ADORA2A (0.55) | ADORA2AADORA1MGLLTNKSTNKS2 | |
| SCHEMBL22410955 | 0.77 | ADORA2A (0.54) | ADORA2AADORA1MGLLTNKSTNKS2 | |
| SCHEMBL22410636 | 0.76 | ADORA2A (0.56) | ADORA2AADORA1MGLLTNKSTNKS2 | |
| SCHEMBL22410904 | 0.75 | ADORA2A (0.54) | ADORA2AADORA1TNKSTNKS2HPGD | |
| SCHEMBL22410613 | 0.75 | ADORA2A (0.54) | ADORA2AADORA1MGLLTNKSTNKS2 | |
| SCHEMBL6848676 | 0.73 | HPGD (0.53) | ADORA2AADORA1MGLLTNKSTNKS2 | |
| SCHEMBL22410661 | 0.73 | ADORA2A (0.55) | ADORA2AADORA1MGLLTNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3938362-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-01-19 | — | — | EP | claimed |
| WO-2020182990-A1 | FUSED RING PYRIMIDONE DERIVATIVES FOR USE IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2020-09-17 | — | — | WO | claimed |