Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 6/20 | 0.57 |
| ▸ | HTR1B | P28222 | 6/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604746 | 0.73 | HTR1B (0.66) | HTR1DHTR1BHTR1AKMT2AMEN1 | |
| SCHEMBL6604742 | 0.73 | HTR1B (0.66) | HTR1DHTR1BHTR1AKMT2AMEN1 | |
| SCHEMBL6605824 | 0.73 | HTR1B (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL6604404 | 0.70 | HTR1B (0.82) | HTR1DHTR1BHTR1AMAPTCYP3A4 | |
| SCHEMBL6604399 | 0.70 | HTR1B (0.82) | HTR1DHTR1BHTR1AMAPTCYP3A4 | |
| SCHEMBL6606934 | 0.70 | HTR1D (0.72) | HTR1DHTR1BHTR1AKMT2AGAA | |
| SCHEMBL6606931 | 0.70 | HTR1D (0.72) | HTR1DHTR1BHTR1AKMT2AGAA | |
| SCHEMBL6604606 | 0.69 | HTR1B (0.78) | HTR1DHTR1BHTR1AMAPTCYP3A4 | |
| SCHEMBL6604602 | 0.69 | HTR1B (0.78) | HTR1DHTR1BHTR1AMAPTCYP3A4 | |
| SCHEMBL6607001 | 0.68 | HTR1B (0.77) | HTR1DHTR1BHTR1AMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |