Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 13/20 | 0.66 |
| ▸ | HTR1D | P28221 | 11/20 | 0.66 |
| ▸ | HTR1A | P08908 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 2/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604742 | 1.00 | HTR1B (0.66) | HTR1BHTR1DHTR1AMEN1KMT2A | |
| SCHEMBL6605824 | 0.80 | HTR1B (1.00) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6605819 | 0.80 | HTR1B (1.00) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL22411005 | 0.73 | HTR1D (0.57) | HTR1BHTR1DHTR1AMEN1KMT2A | |
| SCHEMBL6603709 | 0.72 | GHSR (0.46) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6603712 | 0.72 | GHSR (0.46) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6603805 | 0.71 | HTR1B (1.00) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6603798 | 0.71 | HTR1B (1.00) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6604399 | 0.70 | HTR1B (0.82) | HTR1BHTR1DHTR1AGHSRWDR5 | |
| SCHEMBL6604404 | 0.70 | HTR1B (0.82) | HTR1BHTR1DHTR1AGHSRWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | claimed |
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | disclosed |