Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | PLG | P00747 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | BHMT | Q93088 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | GRM8 | O00222 | 1/20 | 0.57 |
| ▸ | GRM6 | O15303 | 1/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8594448 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Lysine SCHEMBL14343193 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Octanedioate SCHEMBL18496728 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Azelaic Acid SCHEMBL3338900 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Pimelic Acid SCHEMBL19031711 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Pimelic Acid SCHEMBL19031710 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Azelaic Acid SCHEMBL3338898 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Lysine SCHEMBL19210217 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Octanedioate SCHEMBL18496726 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Sebacic Acid SCHEMBL5379246 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3934675-A2 | ZILUCOPLAN AS DEEP TISSUE PENETRATING C5 INHIBITOR | RA Pharmaceuticals, Inc. (US) | 2022-01-12 | — | — | EP | disclosed |
| WO-2020185541-A2 | MODULATORS OF COMPLEMENT ACTIVITY | RA PHARMACEUTICALS, INC. (US) | 2020-09-17 | — | — | WO | disclosed |