Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Azelaic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | PLG | P00747 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | BHMT | Q93088 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | GRM8 | O00222 | 1/20 | 0.57 |
| ▸ | GRM6 | O15303 | 1/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8594448 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Lysine SCHEMBL14343193 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Octanedioate SCHEMBL18496728 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Pimelic Acid SCHEMBL19031711 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Pimelic Acid SCHEMBL19031710 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Azelaic Acid SCHEMBL3338898 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Lysine SCHEMBL19210217 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Octanedioate SCHEMBL18496726 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Lysine SCHEMBL22411244 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 | |
| Sebacic Acid SCHEMBL5379246 | 1.00 | GSR (0.77) | GSRLMNATHRBKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115708783-A | Formula of liquid crystal emulsifier composition and application of liquid crystal emulsifier composition in cosmetics | 美特瑞生物科技(上海)有限公司 | 2023-02-24 | — | — | CN | claimed |
| US-20060159714-A1 | Use of an antioxidant in a dermatological and/or cosmetic composition | THOREL JEAN-NOEL | 2006-07-20 | — | — | US | claimed |
| WO-2026100897-A1 | LYSINE DECARBOXYLASE DERIVED FROM PANTOEA ALHAGI AND METHOD FOR PRODUCING CADAVERINE USING MICROORGANISM COMPRISING SAME | 씨제이제일제당 (주) | 2026-05-15 | — | — | WO | disclosed |
| US-20250275904-A1 | ANTI-SUN COSMETIC COMPOSITION CONTAINING MYCOSPORINE-LIKE AMINO ACIDS | Thorel, Jean-Noël (FR) | 2025-09-04 | — | — | US | disclosed |
| US-20250049685-A1 | COLLAGEN LOTION FORMULATIONS AND METHODS OF USE THEREOF | Wellbeam Consumer Health Intermediate, LLC (US) | 2025-02-13 | — | — | US | disclosed |
| US-20250049684-A1 | COLLAGEN CREAM FORMULATIONS AND METHODS OF USE THEREOF | Wellbeam Consumer Health Intermediate, LLC (US) | 2025-02-13 | — | — | US | disclosed |
| US-20250049686-A1 | COLLAGEN SERUM FORMULATIONS AND METHODS OF USE THEREOF | Wellbeam Consumer Health Intermediate, LLC (US) | 2025-02-13 | — | — | US | disclosed |
| EP-4389214-A2 | USE OF TRIMETHOXYBENZYL ACETYLSINAPATE, ADVANTAGEOUSLY IN COMBINATION WITH AT LEAST ONE SUNSCREEN, FOR PROTECTING THE SKIN | Thorel, Jean-Noël (FR) | 2024-06-26 | — | — | EP | disclosed |
| EP-4366686-A1 | ANTI-SUN COSMETIC COMPOSITION CONTAINING MYCOSPORINE-LIKE AMINO ACIDS | NAOS Institute of Life Science (FR) | 2024-05-15 | — | — | EP | disclosed |
| EP-3466419-B1 | USE OF TRIMETHOXYBENZYL ACETYLSINAPATE, ADVANTAGEOUSLY IN COMBINATION WITH AT LEAST ONE SUNSCREEN, FOR PROTECTING THE SKIN | THOREL JEAN NOEL (FR) | 2024-05-08 | — | — | EP | disclosed |
| US-20240041727-A1 | GLYCOSYLATED BACTERIORUBERINS AND INDUSTRIAL APPLICATIONS THEREOF | NAOS INSTITUTE OF LIFE SCIENCE (FR) | 2024-02-08 | — | — | US | disclosed |
| CN-1819824-B | Use of antioxidants in dermatological and/or cosmetic compositions | JEAN-NOEL THOREL | 2010-05-12 | — | — | CN | disclosed |
| EP-2120846-A2 | USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS | BASF SE (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008107347-A2 | USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS | BASF SE (CH) | 2008-09-12 | — | — | WO | disclosed |
| CN-1819824-A | Use of antioxidants in dermatological and/or cosmetic compositions | JEAN-NOEL THOREL (FR) | 2006-08-16 | — | — | CN | disclosed |
| US-20060159714-A1 | Use of an antioxidant in a dermatological and/or cosmetic composition | THOREL JEAN-NOEL | 2006-07-20 | — | — | US | disclosed |
| US-20060159714-A1 | Use of an antioxidant in a dermatological and/or cosmetic composition | THOREL JEAN-NOEL | 2006-07-20 | — | — | US | disclosed |
| EP-1641476-A2 | USE OF AN ANTIOXIDANT IN A DERMATOLOGICAL AND/OR COSMETIC COMPOSITION | Thorel, Jean-Noel (FR) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005004891-A3 | USE OF AN ANTIOXIDANT IN A DERMATOLOGICAL AND/OR COSMETIC COMPOSITION | THOREL JEAN-NOEL (FR) | 2005-06-09 | — | — | WO | disclosed |
| WO-2005004891-A2 | USE OF AN ANTIOXIDANT IN A DERMATOLOGICAL AND/OR COSMETIC COMPOSITION | THOREL JEAN-NOEL (FR) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250275904-A1 | ANTI-SUN COSMETIC COMPOSITION CONTAINING MYCOSPORINE-LIKE AMINO ACIDS | CUTA, MYC, XPA | GSR 3946/4885LMNA 1602/4885THRB 4524/4885 |
| US-20240041727-A1 | GLYCOSYLATED BACTERIORUBERINS AND INDUSTRIAL APPLICATIONS THEREOF | BPGM, DDOST, UGGT1 | GSR 2389/4885LMNA 4116/4885THRB 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.