Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22411339 | 0.87 | MBOAT4 (0.37) | MBOAT4JAK2IDH1GRM4TRPA1 | |
| SCHEMBL22411327 | 0.73 | MEN1 (0.39) | — | |
| SCHEMBL22428683 | 0.66 | GRM4 (0.39) | MBOAT4JAK2IDH1GRM4TRPA1 | |
| SCHEMBL8741944 | 0.58 | HIF1A (0.30) | — | |
| SCHEMBL7131055 | 0.58 | PDE10A (0.44) | — | |
| SCHEMBL23851628 | 0.56 | AAK1 (0.40) | MBOAT4IDH1 | |
| SCHEMBL12747825 | 0.56 | KCNH2 (0.39) | MBOAT4 | |
| SCHEMBL6195640 | 0.56 | KCNH2 (0.43) | — | |
| SCHEMBL23884996 | 0.55 | CHRM4 (0.32) | IDH1GRM4 | |
| SCHEMBL28313616 | 0.55 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022020150-A1 | METHODS OF EXTENDING LIFESPAN BY ADMINISTERING FERROPTOSIS INHIBITORS | COLLABORATIVE MEDICINAL DEVELOPMENT, LLC (US) | 2022-01-27 | — | — | WO | disclosed |
| EP-3938340-A1 | HETEROAROMATIC AND HETEROBICYCLIC AROMATIC DERIVATIVES FOR THE TREATMENT OF FERROPTOSIS-RELATED DISORDERS | Collaborative Medicinal Development, LLC (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2020185738-A1 | HETEROAROMATIC AND HETEROBICYCLIC AROMATIC DERIVATIVES FOR THE TREATMENT OF FERROPTOSIS-RELATED DISORDERS | COLLABORATIVE MEDICINAL DEVELOPMENT, LLC (US) | 2020-09-17 | — | — | WO | disclosed |