Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TPMT | P51580 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29684130 | 1.00 | MEN1 (0.39) | MEN1KMT2ATPMTHCAR3SRD5A2 | |
| SCHEMBL22411916 | 0.87 | PPARA (0.37) | MEN1KMT2ATPMTACACBALDH1A1 | |
| SCHEMBL22411915 | 0.87 | PPARA (0.37) | MEN1KMT2ATPMTACACBALDH1A1 | |
| SCHEMBL28669236 | 0.83 | KMT2A (0.36) | MEN1KMT2ATPMTHCAR3SRD5A2 | |
| SCHEMBL22411905 | 0.82 | ALDH1A1 (0.36) | MEN1KMT2ATPMTSRD5A2ALDH1A1 | |
| SCHEMBL22411902 | 0.82 | ALDH1A1 (0.36) | MEN1KMT2ATPMTSRD5A2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL22411875 | 0.81 | TPMT (0.36) | MEN1KMT2ATPMTHCAR3SRD5A2 | |
| SCHEMBL22411917 | 0.79 | SRD5A2 (0.36) | MEN1KMT2ATPMTHCAR3SRD5A2 | |
| SCHEMBL22411874 | 0.73 | CREBBP (0.37) | MEN1KMT2AHCAR3ALDH1A1HTT | |
| SCHEMBL5210174 | 0.73 | TPMT (0.43) | MEN1KMT2ATPMTSRD5A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250276977-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC (US) | 2025-09-04 | — | — | US | disclosed |
| US-20220177486-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2022-06-09 | — | — | US | disclosed |
| EP-3938369-A1 | TYK2 INHIBITORS AND USES THEREOF | Esker Therapeutics, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2020185755-A1 | TYK2 INHIBITORS AND USES THEREOF | FRONTHERA U.S. PHARMACEUTICALS LLC (US) | 2020-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250276977-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | MEN1 1061/4885KMT2A 42/4885TPMT 177/4885 |
| US-20220177486-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | MEN1 1061/4885KMT2A 42/4885TPMT 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.