SCHEMBL22413623

SCHEMBL22413623

CN[C@@H](CCCNC(=N)N)CC(C)C

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KISS1R Q969F8 1/20 0.39
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NPY4R P50391 12/20 0.36
NPY1R P25929 9/20 0.36
NPY5R Q15761 8/20 0.36
NPY2R P49146 5/20 0.36
ALOX15 P16050 1/20 0.34
CACNA1B Q00975 2/20 0.33
ITGB3 P05106 1/20 0.33
ITGA2B P08514 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20104610 0.84 MEN1 (0.36) KISS1RMEN1CYP1A2KMT2ASMN1; SMN2
SCHEMBL20099658 0.84 MEN1 (0.38) MEN1CYP1A2KMT2ASMN1; SMN2ALOX15
SCHEMBL23436545 0.83 MEN1 (0.35) KISS1RMEN1CYP1A2KMT2ASMN1; SMN2
SCHEMBL23436544 0.82 MEN1 (0.37) MEN1CYP1A2KMT2ASMN1; SMN2ALOX15
SCHEMBL7935092 0.81 MEN1 (0.44) MEN1CYP1A2KMT2ASMN1; SMN2NPY4R
SCHEMBL21973636 0.80 NPY4R (0.41) MEN1CYP1A2KMT2ASMN1; SMN2NPY4R
SCHEMBL20763852 0.80 NPY4R (0.41) MEN1CYP1A2KMT2ASMN1; SMN2NPY4R
SCHEMBL11980626 0.79 MEN1 (0.40) MEN1CYP1A2KMT2ASMN1; SMN2NPY4R
SCHEMBL13347956 0.78 ALOX15 (0.35) KISS1RMEN1CYP1A2KMT2ASMN1; SMN2
SCHEMBL18758145 0.77 NPY4R (0.41) KISS1RNPY4RNPY1RNPY5RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11767354-B2 Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors JANSSEN PHARMACEUTICA NV (BE) 2023-09-26 US disclosed
US-11591379-B2 Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors JANSSEN PHARMACEUTICA NV (BE) 2023-02-28 US disclosed
US-20210253661-A1 GLUCAGON LIKE PEPTIDE 1 (GLP-1) FUSION PEPTIDE COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE CONJUGATES AND USES THEREOF Janssen Sciences Ireland Unlimited Company (IE) 2021-08-19 US disclosed
US-20210163566-A1 Antibody-Coupled Cyclic Peptide Tyrosine Tyrosine Compounds as Modulators of Neuropeptide Y Receptors JANSSEN PHARMACEUTICA NV (BE) 2021-06-03 US disclosed
US-20200283491-A1 ANTIBODY-COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS JANSSEN PHARMACEUTICA NV (BE) 2020-09-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210253661-A1 GLUCAGON LIKE PEPTIDE 1 (GLP-1) FUSION PEPTIDE COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE CONJUGATES AND USES THEREOF GLP1R, GIPR, IAPP KISS1R 249/4885MEN1 1397/4885CYP1A2 4757/4885
US-20200283491-A1 ANTIBODY-COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS NPY1R, NPY5R, NPY2R KISS1R 228/4885MEN1 1303/4885CYP1A2 4749/4885
US-11591379-B2 Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors NPY1R, NPY5R, NPY2R KISS1R 228/4885MEN1 1303/4885CYP1A2 4749/4885
US-20210163566-A1 Antibody-Coupled Cyclic Peptide Tyrosine Tyrosine Compounds as Modulators of Neuropeptide Y Receptors NPY1R, NPY5R, NPY2R KISS1R 228/4885MEN1 1303/4885CYP1A2 4749/4885
US-11767354-B2 Antibody-coupled cyclic peptide tyrosine tyrosine compounds as modulators of neuropeptide Y receptors NPY1R, NPY5R, NPY2R KISS1R 228/4885MEN1 1303/4885CYP1A2 4749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.