Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.64 |
| ▸ | HPGD | P15428 | 12/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.64 |
| ▸ | MEN1 | O00255 | 9/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 9/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.56 |
| ▸ | RELA | Q04206 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22415523 | 0.86 | MAPT (0.76) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10357883 | 0.84 | MAPT (0.76) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL22415617 | 0.84 | MAPT (0.64) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL22415570 | 0.84 | MAPT (0.76) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10357612 | 0.83 | MAPT (0.67) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3589281 | 0.82 | MEN1 (0.56) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17938568 | 0.81 | MEN1 (0.66) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6333836 | 0.81 | KMT2A (0.55) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL22415371 | 0.80 | MAPT (0.59) | MAPTHPGDKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10357964 | 0.79 | MEN1 (0.76) | MAPTHPGDKMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3705476-A1 | 2-(1H-PYRAZOL-3-YL) PHENOL COMPOUND AND USE THEREOF | Beijing Jialin Pharmaceutical Inc. (CN) | 2020-09-09 | — | — | EP | disclosed |