Sugi Predict

Sugi Predict / Compounds / SCHEMBL10357883

SCHEMBL10357883

SCHEMBL10357883

Cc1ccccc1-c1cc(-c2cc(F)ccc2O)n[nH]1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 13/20 0.76
▸ ALOX15 P16050 12/20 0.76
▸ KMT2A Q03164 12/20 0.76
▸ MEN1 O00255 11/20 0.76
▸ HPGD P15428 9/20 0.76
▸ USP2 O75604 4/20 0.76
▸ SMN1; SMN2 Q16637 10/20 0.74
▸ RAB9A P51151 6/20 0.74
▸ NFKB1 P19838 4/20 0.74
▸ NFKB2 Q00653 4/20 0.74
▸ RELA Q04206 4/20 0.74
▸ TSHR P16473 1/20 0.74
▸ NPC1 O15118 6/20 0.65
▸ NPSR1 Q6W5P4 5/20 0.65
▸ LMNA P02545 3/20 0.65
▸ TP53 P04637 2/20 0.65
▸ GLA P06280 1/20 0.65
▸ L3MBTL1 Q9Y468 1/20 0.65
▸ CASP3 P42574 2/20 0.64
▸ SENP8 Q96LD8 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22415613 0.86 MAPT (0.56) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL10358110 0.86 MAPT (1.00) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL22415523 0.86 MAPT (0.76) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL10357589 0.86 SMN1; SMN2 (1.00) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL22415373 0.85 KMT2A (0.66) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL22415570 0.84 MAPT (0.76) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL22415345 0.84 MAPT (0.64) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL22415617 0.84 MAPT (0.64) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL10357612 0.83 MAPT (0.67) MAPTALOX15KMT2AMEN1HPGD
SCHEMBL22415391 0.82 ALOX15 (0.57) MAPTALOX15KMT2AMEN1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11332461-B2 2-(1H-pyrazol-3-yl) phenol compound and use thereof BEIJING JIALIN PHARMACEUTICAL INC. (CN) 2022-05-17 — — US disclosed
US-20200354342-A1 2-(1H-PYRAZOL-3-YL) PHENOL COMPOUND AND USE THEREOF BEIJING JIALIN PHARMACEUTICAL INC. (CN) 2020-11-12 — — US disclosed
EP-3705476-A1 2-(1H-PYRAZOL-3-YL) PHENOL COMPOUND AND USE THEREOF Beijing Jialin Pharmaceutical Inc. (CN) 2020-09-09 — — EP disclosed
US-20120184583-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120184583-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 MAPT 4385/4885ALOX15 3215/4885KMT2A 4334/4885
US-11332461-B2 2-(1H-pyrazol-3-yl) phenol compound and use thereof VHL, PAH, TP53 MAPT 2084/4885ALOX15 2140/4885KMT2A 1208/4885
US-20200354342-A1 2-(1H-PYRAZOL-3-YL) PHENOL COMPOUND AND USE THEREOF VHL, PAH, TP53 MAPT 2084/4885ALOX15 2140/4885KMT2A 1208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.