Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.51 |
| ▸ | HRH2 | P25021 | 9/20 | 0.51 |
| ▸ | HRH1 | P35367 | 9/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22415973 | 0.84 | DRD3 (0.65) | DRD3DRD2CYP2D6TSHRNFKB1 | |
| SCHEMBL6134283 | 0.83 | HRH3 (0.60) | HRH3HRH2HRH1SIGMAR1DRD3 | |
| SCHEMBL14544193 | 0.82 | DRD2 (0.47) | HRH3DRD3DRD2CYP2D6 | |
| SCHEMBL22415999 | 0.81 | DRD2 (0.60) | SIGMAR1DRD3DRD2CYP2D6 | |
| SCHEMBL30010274 | 0.81 | DRD2 (0.50) | DRD3DRD2 | |
| SCHEMBL22415828 | 0.81 | DRD2 (0.50) | DRD3DRD2 | |
| SCHEMBL14321119 | 0.81 | DRD2 (0.46) | HRH1DRD3DRD2CYP2D6 | |
| SCHEMBL21148130 | 0.81 | SLC18A3 (0.57) | SIGMAR1DRD3DRD2CYP2D6TSHR | |
| SCHEMBL18468495 | 0.81 | SLC18A3 (0.57) | SIGMAR1DRD3DRD2CYP2D6TSHR | |
| SCHEMBL22415827 | 0.81 | DRD3 (0.43) | HRH3HRH2HRH1DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3409670-B1 | N-PYRROLIDINYL, N'-PYRAZOLYL- UREA COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2020-09-09 | — | — | EP | disclosed |