SCHEMBL22416009

SCHEMBL22416009

C=C(C)c1cc(-c2ccc(C3CCC(C)CC3)cc2F)cc(F)c1N=C=S

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FASN P49327 1/20 0.36
CYP3A4 P08684 2/20 0.33
CYP2C9 P11712 2/20 0.33
ESR2 Q92731 1/20 0.32
APP P05067 2/20 0.31
CYP2D6 P10635 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18626210 0.89 FASN (0.38) FASNCYP3A4CYP2C9ESR2APP
SCHEMBL14015550 0.89 FASN (0.38) FASNCYP3A4CYP2C9ESR2APP
SCHEMBL22666561 0.83 FASN (0.39) FASNCYP3A4CYP2C9ESR2APP
SCHEMBL22666481 0.81 ESR2 (0.33) ESR2
SCHEMBL22666394 0.80 ESR2 (0.38) ESR2
SCHEMBL18622097 0.78 FASN (0.39) FASNCYP3A4CYP2C9ESR2APP
SCHEMBL23510880 0.78 CYP3A4 (0.33) CYP3A4CYP2C9APP
SCHEMBL25056660 0.77 CYP3A4 (0.33) FASNCYP3A4CYP2C9APPCYP2D6
SCHEMBL22416048 0.77 NAAA (0.34) ESR2CYP2C19
SCHEMBL22666411 0.77 APP (0.36) CYP3A4CYP2C9ESR2APPCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3543314-B1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2020-09-09 EP disclosed