Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 17/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22419538 | 0.88 | NAMPT (0.63) | NAMPTCYP2C9HDAC3HDAC1HDAC2 | |
| SCHEMBL21524157 | 0.88 | NAMPT (0.79) | NAMPTCYP2C9HDAC3HDAC1HDAC2 | |
| SCHEMBL20953203 | 0.86 | NAMPT (0.65) | NAMPTCYP2C9HDAC3HDAC1HDAC2 | |
| SCHEMBL16107708 | 0.84 | NAMPT (0.77) | NAMPTCYP2C9 | |
| SCHEMBL168775 | 0.84 | NAMPT (0.78) | NAMPTCYP2C9 | |
| SCHEMBL15530934 | 0.84 | NAMPT (0.78) | NAMPTCYP2C9 | |
| SCHEMBL12467922 | 0.82 | NAMPT (0.78) | NAMPTCYP2C9 | |
| SCHEMBL22419555 | 0.81 | NAMPT (0.74) | NAMPTCYP2C9HDAC3HDAC1HDAC2 | |
| SCHEMBL22419530 | 0.80 | NAMPT (0.73) | NAMPTCYP2C9 | |
| SCHEMBL20953292 | 0.79 | NAMPT (0.77) | NAMPTCYP2C9HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10772874-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10772874-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | NAMPT 1/4885CYP2C9 725/4885HDAC3 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.