Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 7/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.42 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16694505 | 0.82 | HIF1A (0.55) | HIF1AEPAS1COXFA4 | |
| SCHEMBL3395050 | 0.79 | CYP19A1 (0.48) | HIF1AEPAS1MEN1MAPTKMT2A | |
| SCHEMBL2009830 | 0.78 | HIF1A (0.52) | HIF1AEPAS1COXFA4PKMMEN1 | |
| SCHEMBL16865542 | 0.78 | HIF1A (0.42) | HIF1AEPAS1COXFA4MAPTSMN1; SMN2 | |
| SCHEMBL5308020 | 0.78 | SMN1; SMN2 (0.46) | HIF1AEPAS1BRD4LMNAGAA | |
| SCHEMBL2093768 | 0.75 | AOC3 (0.59) | BRD4PKMTSHRAOC3 | |
| SCHEMBL9582367 | 0.72 | HIF1A (0.45) | HIF1AEPAS1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL9869481 | 0.72 | HIF1A (0.38) | HIF1AEPAS1TDP1 | |
| SCHEMBL4825734 | 0.71 | CTNNB1 (0.52) | PKMMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4824905 | 0.71 | KMT2A (0.52) | MEN1LMNAMAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10772858-B2 | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10772858-B2 | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors | HIF1A, HIF1AN, EGLN2 | HIF1A 1/4885EPAS1 26/4885COXFA4 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.