Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20504502 | 0.85 | TYK2 (0.45) | TYK2PDE4DMAPTGAATP53 | |
| SCHEMBL20504497 | 0.83 | TYK2 (0.39) | TYK2PDE4DMAPTGAAALDH1A1 | |
| SCHEMBL22421810 | 0.78 | PI4KB (0.50) | MAPTGAAALDH1A1KDM4ETP53 | |
| SCHEMBL17849953 | 0.71 | TYK2 (0.49) | TYK2PDE4DMAPTMAPK1HSD17B10 | |
| SCHEMBL3314483 | 0.71 | TYK2 (0.48) | TYK2PDE4D | |
| SCHEMBL2359901 | 0.70 | EGFR (0.36) | PDE4DMEN1KMT2AEGFR | |
| SCHEMBL2358706 | 0.69 | TYK2 (0.51) | TYK2PDE4DDYRK1A | |
| SCHEMBL3313276 | 0.69 | CSNK2A2 (0.39) | TYK2PDE4DMAPTGAATP53 | |
| SCHEMBL3312258 | 0.69 | TYK2 (0.48) | TYK2PDE4DPIM1 | |
| SCHEMBL3318537 | 0.68 | TYK2 (0.37) | TYK2PDE4DJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377496-B1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2020-09-16 | — | — | EP | disclosed |