Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 4/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18281301 | 0.75 | AKR1B1 (0.46) | TP53PDE2ALMNA | |
| SCHEMBL18282876 | 0.71 | PDE2A (0.43) | CDK4CCND1PDE2ACRHBPCRHR2 | |
| SCHEMBL18282703 | 0.66 | PDE2A (0.49) | PDE2A | |
| SCHEMBL18282842 | 0.65 | PDE2A (0.46) | CDK4CCND1PDE2APDE5ACRHBP | |
| SCHEMBL18283297 | 0.64 | CDK4 (0.44) | HTTPOLBATMCDK4CCND1 | |
| SCHEMBL18281355 | 0.62 | PDE2A (0.54) | CDK4CCND1PDE2A | |
| SCHEMBL6708585 | 0.62 | CDK4 (0.52) | CDK4CCND1PDE5AALDH1A1 | |
| SCHEMBL18282713 | 0.62 | PDE2A (0.57) | PDE2A | |
| SCHEMBL18283205 | 0.60 | PDE2A (0.77) | PDE2A | |
| SCHEMBL20150739 | 0.59 | LMNA (0.44) | HTTCDK4CCND1TP53PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302484-B1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |