Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR39 | O43194 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 6/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22411318 | 0.82 | TYRO3 (0.59) | MERTKAXLTYRO3TLR7 | |
| SCHEMBL22411411 | 0.81 | KMT2A (0.47) | KDM4EGAAADORA3ADORA2AADORA1 | |
| SCHEMBL22872852 | 0.80 | KMT2A (0.49) | KDM4EGAAADORA3ADORA2AADORA1 | |
| SCHEMBL22411415 | 0.78 | JAK2 (0.39) | KDM4EGAAMERTKADORA3ADORA2A | |
| SCHEMBL22872907 | 0.78 | GBA1 (0.49) | — | |
| SCHEMBL22411399 | 0.77 | CTSL (0.52) | — | |
| SCHEMBL22872905 | 0.75 | LATS1 (0.60) | KDM4EKMT2A | |
| SCHEMBL22428693 | 0.75 | TLR8 (0.38) | MERTKADORA3ADORA2ATLR7MAPK8 | |
| SCHEMBL22411416 | 0.74 | MAPK8 (0.38) | KDM4EGAAADORA3ADORA2APDE4A | |
| SCHEMBL22872893 | 0.74 | MAP4K4 (0.49) | KDM4EGAAADORA3ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020185738-A1 | HETEROAROMATIC AND HETEROBICYCLIC AROMATIC DERIVATIVES FOR THE TREATMENT OF FERROPTOSIS-RELATED DISORDERS | COLLABORATIVE MEDICINAL DEVELOPMENT, LLC (US) | 2020-09-17 | — | — | WO | disclosed |