Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | ACR | P10323 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262827 | 1.00 | NPC1 (0.48) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL13531263 | 1.00 | NPC1 (0.48) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL1531820 | 1.00 | NPC1 (0.48) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL13572533 | 0.94 | GAA (0.47) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL1531871 | 0.92 | HTT (0.43) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL14016039 | 0.90 | NPC1 (0.61) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL22341181 | 0.90 | NPC1 (0.61) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL22435487 | 0.90 | LMNA (0.48) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL21993579 | 0.90 | MAPT (0.45) | NPC1LMNAMAPTNFKB1NFKB2 | |
| SCHEMBL29797124 | 0.89 | NPC1 (0.47) | NPC1LMNAMAPTNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8613868-B2 | Mesogenic stabilizers | TRANSITIONS OPTICAL, INC (US) | 2013-12-24 | — | — | US | disclosed |
| WO-2013022610-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2013-02-14 | — | — | WO | disclosed |
| WO-2013022605-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2013-02-14 | — | — | WO | disclosed |
| US-8349210-B2 | Mesogenic stabilizers | TRANSITIONS OPTICAL, INC. (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120021144-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120003401-A1 | MESOGENIC STABILIZERS | TRANSITIONS OPTICAL, INC. (US) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120021144-A1 | MESOGENIC STABILIZERS | C1S, C5, CCNL2 | NPC1 2614/4885LMNA 260/4885MAPT 1278/4885 |
| US-20120003401-A1 | MESOGENIC STABILIZERS | PYM1, BMI1, C1S | NPC1 2278/4885LMNA 1310/4885MAPT 1853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.