Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.73 |
| ▸ | MEN1 | O00255 | 6/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.73 |
| ▸ | GLA | P06280 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22425 | 0.89 | MAPT (0.64) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19445043 | 0.81 | MAPT (0.81) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL5960621 | 0.76 | TNFRSF1A (0.62) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL2475992 | 0.76 | KDM4E (0.58) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL2088159 | 0.76 | ALDH1A1 (0.76) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL30161844 | 0.76 | ALDH1A1 (0.76) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL15454599 | 0.76 | MAPT (0.72) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL11755034 | 0.76 | KDM4E (0.72) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL23723 | 0.76 | KDM4E (0.58) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7057299 | 0.75 | SMN1; SMN2 (0.50) | MAPTALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |