Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.41 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24415104 | 0.85 | NR1H2 (0.39) | NR1H2F12ADORA1ESR2USP2 | |
| SCHEMBL31492977 | 0.84 | MAPK1 (0.39) | NR1H2F12ADORA1ESR2USP2 | |
| SCHEMBL31616837 | 0.79 | NR1H2 (0.41) | NR1H2F12ADORA1MAP4K4SMARCA2 | |
| SCHEMBL19632111 | 0.75 | NR1H2 (0.45) | NR1H2F12ADORA1MAP4K4SMARCA2 | |
| SCHEMBL16711291 | 0.74 | CSNK1E (0.43) | — | |
| SCHEMBL27191792 | 0.74 | HTT (0.42) | NR1H2F12ESR2USP2SMN1; SMN2 | |
| SCHEMBL30752622 | 0.74 | ADORA1 (0.39) | NR1H2F12ADORA1ESR2USP2 | |
| SCHEMBL26645063 | 0.74 | NR1H2 (0.38) | NR1H2F12ADORA1ESR2USP2 | |
| SCHEMBL16699166 | 0.73 | ADORA1 (0.44) | NR1H2ADORA1ESR2USP2SMN1; SMN2 | |
| SCHEMBL31368516 | 0.72 | NR1H2 (0.45) | NR1H2F12ADORA1MAP4K4SMARCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020185606-A1 | MACROCYCLIC COMPOUNDS | ZENO MANAGEMENT, INC. (US) | 2020-09-17 | — | — | WO | disclosed |