Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19556564 | 1.00 | ATF4 (0.48) | ATF4KDM4EMAPTRXFP1CYP3A4 | |
| SCHEMBL30961490 | 0.91 | ATF4 (0.50) | ATF4 | |
| SCHEMBL22396872 | 0.91 | ATF4 (0.50) | ATF4 | |
| SCHEMBL19569384 | 0.91 | ATF4 (0.50) | ATF4 | |
| SCHEMBL22437092 | 0.90 | ATF4 (0.51) | ATF4 | |
| SCHEMBL19556288 | 0.90 | ATF4 (0.51) | ATF4 | |
| SCHEMBL19555955 | 0.90 | ATF4 (0.52) | ATF4 | |
| SCHEMBL19556477 | 0.89 | ATF4 (0.51) | ATF4 | |
| SCHEMBL22437038 | 0.89 | ATF4 (0.51) | ATF4 | |
| SCHEMBL22396986 | 0.88 | ATF4 (0.47) | ATF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-23 | — | — | EP | disclosed |