Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 18/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19556216 | 1.00 | ATF4 (0.47) | ATF4BACE1BACE2 | |
| SCHEMBL19556472 | 0.92 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19556146 | 0.92 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19556430 | 0.92 | ATF4 (0.48) | ATF4 | |
| SCHEMBL19556494 | 0.89 | ATF4 (0.46) | ATF4 | |
| SCHEMBL22436934 | 0.89 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19556325 | 0.88 | ATF4 (0.54) | ATF4 | |
| SCHEMBL19556524 | 0.86 | ATF4 (0.58) | ATF4 | |
| SCHEMBL19569670 | 0.84 | ATF4 (0.59) | ATF4 | |
| SCHEMBL19556404 | 0.82 | ATF4 (0.39) | ATF4BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-23 | — | — | EP | disclosed |