Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22441642 | 0.95 | KMT2A (0.64) | HDAC1HDAC8KMT2AMEN1LMNA | |
| SCHEMBL22441857 | 0.89 | THRB (0.68) | HDAC1HDAC8KMT2AMEN1LMNA | |
| SCHEMBL22441781 | 0.87 | HDAC1 (0.64) | HDAC1HDAC8KMT2AMEN1LMNA | |
| SCHEMBL1403125 | 0.85 | HDAC3 (0.78) | HDAC1HDAC8THRBHTTHDAC3 | |
| SCHEMBL1403126 | 0.85 | HDAC3 (0.78) | HDAC1HDAC8THRBHTTHDAC3 | |
| SCHEMBL24264943 | 0.84 | MAOB (0.70) | HDAC1HDAC8KMT2AMEN1LMNA | |
| SCHEMBL22455060 | 0.84 | HDAC1 (0.58) | HDAC1HDAC8KMT2AMEN1LMNA | |
| SCHEMBL1402914 | 0.82 | HDAC2 (0.78) | HDAC1HDAC8KMT2AMEN1LMNA | |
| SCHEMBL29378463 | 0.82 | HDAC2 (0.78) | HDAC1HDAC8KMT2AMEN1LMNA | |
| SCHEMBL1402915 | 0.82 | HDAC2 (0.78) | HDAC1HDAC8KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200299282-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ANTIDOTE IP HOLDINGS LLC (US) | 2020-09-24 | — | — | US | disclosed |
| US-20200299282-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | ANTIDOTE IP HOLDINGS LLC (US) | 2020-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200299282-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | VHL, TP53, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | HDAC1 47/4885HDAC8 59/4885KMT2A 702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.