SCHEMBL22444693

SCHEMBL22444693

COC(=O)C(N)Cc1cc(F)c(OC)c(F)c1

nearest known ligand 0.48

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.47
ACACB O00763 1/20 0.45
SLC7A5 Q01650 3/20 0.40
PPARD Q03181 1/20 0.38
PPARA Q07869 1/20 0.38
TUBB1 Q9H4B7 2/20 0.37
CHRM4 P08173 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17054157 0.87 ALDH1A1 (0.46) ALDH1A1SLC7A5
SCHEMBL14032566 0.86 ALDH1A1 (0.45) ALDH1A1SLC7A5
SCHEMBL5112269 0.86 ALDH1A1 (0.45) ALDH1A1SLC7A5
SCHEMBL22444755 0.86 SLC7A5 (0.51) ALDH1A1SLC7A5
SCHEMBL22444675 0.85 ACACB (0.38) ALDH1A1ACACBTUBB1CHRM4
Hydrochloric Acid SCHEMBL5112261 0.84 ALDH1A1 (0.47) ALDH1A1SLC7A5
Hydrochloric Acid SCHEMBL5112267 0.84 ALDH1A1 (0.47) ALDH1A1SLC7A5
SCHEMBL9162838 0.83 ALDH1A1 (0.54) ALDH1A1
SCHEMBL9162835 0.83 ALDH1A1 (0.54) ALDH1A1
SCHEMBL3967937 0.82 ALDH1A1 (0.47) ALDH1A1SLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113692401-A Process for producing aromatic amino acid derivative 中外制药株式会社 2021-11-23 CN disclosed
WO-2020189540-A1 METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE 中外製薬株式会社 2020-09-24 WO disclosed