Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.35 |
| ▸ | HTR2B | P41595 | 6/20 | 0.35 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | HTR1A | P08908 | 5/20 | 0.35 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2250524 | 0.81 | NPC1 (0.30) | — | |
| SCHEMBL2246374 | 0.81 | — | — | |
| SCHEMBL2245817 | 0.79 | ACHE (0.36) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL2246021 | 0.77 | ACHE (0.36) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL2248292 | 0.75 | — | — | |
| SCHEMBL2249013 | 0.70 | DYRK1A (0.31) | — | |
| SCHEMBL2252216 | 0.70 | DYRK1A (0.31) | — | |
| SCHEMBL3386450 | 0.70 | HTR1D (0.40) | HTR2CHTR2BHTR2AHTR1AHTR1D | |
| SCHEMBL2248413 | 0.66 | RPS6KB2 (0.31) | — | |
| SCHEMBL2244541 | 0.64 | CA12 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989451-B2 | Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments | AUCKLAND UNISERVICES LIMITED (NZ) | 2011-08-02 | — | — | US | claimed |
| US-7989451-B2 | Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments | AUCKLAND UNISERVICES LIMITED (NZ) | 2011-08-02 | — | — | US | disclosed |