Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | TET3 | O43151 | 2/20 | 0.56 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.56 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.56 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.56 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.56 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.56 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.47 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.47 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22173964 | 0.96 | TET3 (0.53) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL22174233 | 0.87 | TET3 (0.51) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL22173975 | 0.86 | EPHX2 (0.56) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL22446341 | 0.85 | EPHX2 (0.49) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL22173988 | 0.85 | EPHX2 (0.49) | KMT2ATET3FBXL19CXXC5TET1 | |
| SCHEMBL22173950 | 0.85 | EPHX2 (0.53) | KMT2ATET3FBXL19CXXC5KDM2B | |
| SCHEMBL27965490 | 0.84 | SMN1; SMN2 (0.57) | KMT2AEPHX2SMN1; SMN2MAPTGAA | |
| SCHEMBL22196904 | 0.83 | JAK3 (0.52) | EPHX2TEAD1TEAD3BTK | |
| SCHEMBL22174118 | 0.83 | EPHX2 (0.58) | EPHX2TEAD1TEAD3EGFRBTK | |
| SCHEMBL22174156 | 0.83 | PARP10 (0.61) | KMT2ARAB9AALDH1A1TEAD1TEAD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11771689-B2 | Cereblon modulators and uses thereof | VIVIDION THERAPEUTICS, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20220298213-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | VIVIDION THERAPEUTICS, INC. | 2022-09-22 | — | — | US | disclosed |
| US-10781239-B2 | In vivo engineered cereblon protein | VIVIDION THERAPEUTICS, INC. (US) | 2020-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298213-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | CRBN, CDR2, DCUN1D4 | KMT2A 607/4885TET3 666/4885FBXL19 247/4885 |
| US-11771689-B2 | Cereblon modulators and uses thereof | CRBN, CBFB, CNN2 | KMT2A 3580/4885TET3 4521/4885FBXL19 3394/4885 |
| US-10781239-B2 | In vivo engineered cereblon protein | CRBN, CDR2, DCUN1D4 | KMT2A 607/4885TET3 666/4885FBXL19 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.