SCHEMBL224464

SCHEMBL224464

CCN(CC)c1ccc(NC(=O)C(C#N)c2ccccc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.57
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
NOX1 Q9Y5S8 4/20 0.57
RAB9A P51151 3/20 0.57
NPY1R P25929 1/20 0.52
NPY2R P49146 1/20 0.52
MAPT P10636 5/20 0.48
CNR2 P34972 2/20 0.47
LMNA P02545 1/20 0.47
TP53 P04637 1/20 0.47
NFKB1 P19838 1/20 0.47
NFKB2 Q00653 1/20 0.47
RELA Q04206 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
ALDH1A1 P00352 5/20 0.47
AKR1C3 P42330 1/20 0.47
AKR1C1 Q04828 1/20 0.47
POLB P06746 4/20 0.47
KDM4E B2RXH2 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL224463 0.95 NPC1 (0.57) NPC1MEN1KMT2ANOX1RAB9A
SCHEMBL28762296 0.83 POLB (0.65) NPC1MEN1KMT2ARAB9AMAPT
SCHEMBL7053950 0.82 ALDH1A1 (0.58) NPC1MEN1KMT2ARAB9AMAPT
SCHEMBL7052543 0.79 KLK7 (0.56) NPC1MEN1KMT2ARAB9AMAPT
SCHEMBL1594108 0.78 SMN1; SMN2 (0.56) NPC1MEN1KMT2ANOX1RAB9A
SCHEMBL7655294 0.76 NPY1R (0.65) NPC1MEN1KMT2ANOX1RAB9A
SCHEMBL1594444 0.75 ALDH1A1 (0.55) NPC1MEN1KMT2ANOX1RAB9A
SCHEMBL9571813 0.75 ALDH1A1 (0.50) NPC1MEN1KMT2ANOX1RAB9A
SCHEMBL7210943 0.74 NPC1 (0.54) NPC1MEN1KMT2ARAB9AMAPT
SCHEMBL17932841 0.74 KMT2A (1.00) NPC1MEN1KMT2ANOX1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120000385-A1 LITHOGRAPHIC PRINTING PLATE MATERIAL AND LITHOGRAPHIC PRINTING PLATE KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2012-01-05 US disclosed
EP-1475232-B1 Lithographic printing plate precursor, method for producing the same and method of lithographic printing FUJIFILM CORP (JP) 2011-08-17 EP disclosed
US-20090075201-A1 PLANOGRAPHIC PRINTING PLATE MATERIAL, AND CYCLIC UREIDE MOIETY-CONTAINING PHENOLIC RESIN AND ITS SYNTHETIC PROCESS KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2009-03-19 US disclosed
EP-1147886-B1 Lithographic printing process FUJIFILM CORP (JP) 2009-01-14 EP disclosed
US-20080274425-A1 Multilayeer; aluminum support with fluoroalkyl acrylic group containing polymer; alkali soluble resin and an acid generator KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2008-11-06 US disclosed
EP-1220041-B1 Method for preparing lithographic printing plate FUJIFILM CORP (JP) 2008-09-17 EP disclosed
US-20080206677-A1 Planographic printing plate material KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2008-08-28 US disclosed
EP-1188580-B1 Aluminum support for planographic printing plate, process for its production, and planographic printing master place FUJIFILM CORP (JP) 2008-08-13 EP disclosed
US-20080182202-A1 Planographic printing plate material and resin used therein KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2008-07-31 US disclosed
US-20080160445-A1 Planographic printing plate material, and method of preparing planographic printing plate employing the same KONICA MINOLTA MEDICAL & GRAPHIC, INC. (JP) 2008-07-03 US disclosed
EP-0511659-A1 Method for processing photosensitive copying materials Fuji Photo Film Co., Ltd. (JP) 1992-11-04 EP disclosed
EP-0487343-A1 Process for preparing a lithographic plate Fuji Photo Film Co., Ltd. (JP) 1992-05-27 EP disclosed
EP-0480388-A2 Light-sensitive litho printing plate requiring no dampening water KONICA CORPORATION (JP) 1992-04-15 EP disclosed
EP-0470581-A2 Aromatic diazo compounds, production method thereof and photosensitive compositions using the same TOYO GOSEI KOGYO CO., LTD. (JP) 1992-02-12 EP disclosed
US-5009981-A Polymerizable photosensitive diazo compound, polymeric binder, photoinitiator KONICA CORPORATION (JP) 1991-04-23 US disclosed
EP-0394923-A2 Photosensitive lithographic printing plate requiring no wetting water KONICA CORPORATION (JP) 1990-10-31 EP disclosed
EP-0394924-A2 Photosensitive lithographic printing plate requiring no wetting water Mitsubishi Chemical Corporation (JP) 1990-10-31 EP disclosed
US-4912013-A Containing a metal complex dye KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1990-03-27 US disclosed
EP-0353873-A1 Photsensitive composition KONICA CORPORATION (JP) 1990-02-07 EP disclosed
US-4797346-A O-NAPHTHOQUINONE DIAZIDE AND NOVALAK RESIN KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1989-01-10 US disclosed