Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | CX3CR1 | P49238 | 2/20 | 0.39 |
| ▸ | PRKCI | P41743 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829998 | 0.93 | TLR8 (0.42) | CRHR1TLR8TLR7LPAR1LPAR2 | |
| SCHEMBL17829990 | 0.88 | TLR8 (0.53) | TLR8TLR7CXCR2CX3CR1KCNH2 | |
| SCHEMBL22448324 | 0.88 | TLR8 (0.53) | TLR8TLR7CXCR2CX3CR1KCNH2 | |
| SCHEMBL22448327 | 0.81 | TLR8 (0.54) | TLR8TLR7KCNH2 | |
| SCHEMBL17829993 | 0.81 | TLR8 (0.54) | TLR8TLR7KCNH2 | |
| SCHEMBL18430122 | 0.80 | TLR8 (0.54) | TLR8TLR7KCNH2 | |
| SCHEMBL22448320 | 0.79 | KCNH2 (0.56) | TLR8TLR7KCNH2 | |
| SCHEMBL17829991 | 0.79 | KCNH2 (0.56) | TLR8TLR7KCNH2 | |
| SCHEMBL7685741 | 0.77 | ESR1 (0.38) | LPAR1LPAR2CXCR2CX3CR1PRKCI | |
| SCHEMBL17830001 | 0.77 | TLR8 (0.44) | CRHR1TLR8TLR7CXCR2CX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3404031-B1 | THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2020-09-23 | — | — | EP | disclosed |