Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.41 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17829997 | 0.93 | TLR8 (0.47) | TLR8TLR7CXCR2KCNH2PDE4A | |
| SCHEMBL18415705 | 0.93 | TLR8 (0.47) | TLR8TLR7CXCR2KCNH2PDE4A | |
| SCHEMBL17829978 | 0.86 | TLR8 (0.60) | TLR8TLR7CXCR2CX3CR1KCNH2 | |
| SCHEMBL17829988 | 0.86 | TLR8 (0.60) | TLR8TLR7CXCR2CX3CR1KCNH2 | |
| SCHEMBL17829986 | 0.79 | TLR8 (0.64) | TLR8TLR7KCNH2 | |
| SCHEMBL17830000 | 0.79 | TLR8 (0.64) | TLR8TLR7KCNH2 | |
| SCHEMBL17829980 | 0.79 | TLR8 (0.64) | TLR8TLR7KCNH2 | |
| SCHEMBL21536319 | 0.78 | KCNH2 (0.63) | TLR8TLR7KCNH2ADORA1 | |
| SCHEMBL22448368 | 0.77 | CRHR1 (0.41) | TLR8TLR7CRHR1CXCR2CX3CR1 | |
| SCHEMBL12510645 | 0.76 | PDE4B (0.46) | CXCR2ADORA2AADORA1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556199-B2 | Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections | JANSSEN SCIENCES IRELAND UC (IE) | 2017-01-31 | — | — | US | disclosed |
| US-20160168164-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168164-A1 | THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS | TYMS, TYMP, UMPS | TLR8 1457/4885TLR7 766/4885CRHR1 4641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.