Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 19/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18975348 | 0.92 | PADI4 (0.59) | PADI4 | |
| SCHEMBL18975351 | 0.90 | PADI4 (0.56) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18938868 | 0.88 | PADI4 (0.54) | PADI4 | |
| SCHEMBL22450519 | 0.86 | PADI4 (0.61) | PADI4 | |
| SCHEMBL18960699 | 0.86 | PADI4 (0.74) | PADI4 | |
| SCHEMBL22450628 | 0.86 | PADI4 (0.52) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18955611 | 0.86 | PADI4 (0.59) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18960751 | 0.86 | PADI4 (0.59) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18955572 | 0.86 | PADI4 (0.59) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18955613 | 0.86 | PADI4 (0.59) | PADI4PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386505-B1 | AZA-BENZIMIDAZOLE INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS INC (US) | 2020-09-23 | — | — | EP | disclosed |