Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20386556 | 0.83 | ALDH1A1 (0.38) | SMN1; SMN2CHRM5ADRA2CALDH1A1KDM4E | |
| SCHEMBL3700457 | 0.74 | KDM4E (0.51) | SMN1; SMN2HPGDKMT2AEPHX1HTT | |
| SCHEMBL3706069 | 0.74 | KDM4E (0.51) | SMN1; SMN2HPGDKMT2AEPHX1HTT | |
| SCHEMBL12398 | 0.74 | KDM4E (0.51) | SMN1; SMN2HPGDKMT2AEPHX1HTT | |
| SCHEMBL12102997 | 0.72 | KMT2A (0.40) | SMN1; SMN2CHRM5ADRA2CHPGDKMT2A | |
| SCHEMBL3704195 | 0.71 | NAMPT (0.50) | SMN1; SMN2KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3698852 | 0.70 | ALDH1A1 (0.51) | SMN1; SMN2HPGDKMT2AEPHX1ALDH1A1 | |
| SCHEMBL3707477 | 0.70 | NAMPT (0.49) | SMN1; SMN2HPGDKMT2AALDH1A1KDM4E | |
| SCHEMBL12676065 | 0.69 | — | — | |
| SCHEMBL7131442 | 0.69 | HPGD (0.41) | CHRM5ADRA2CHPGDKMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023230432-A1 | DR5 AGONIST AND IAP ANTAGONIST COMBINATION THERAPY | Inhibrx, Inc. (US) | 2023-11-30 | — | — | WO | disclosed |
| EP-3936126-A1 | COMBINATION OF IAP INHIBITOR AND IMMUNE CHECKPOINT INHIBITOR | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2022-01-12 | — | — | EP | disclosed |
| EP-3712162-A1 | SMAC MIMETICS USED AS IAP INHIBITORS AND USE THEREOF | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2020-09-23 | — | — | EP | disclosed |