Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245273 | 0.84 | BRD4 (0.41) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2907371 | 0.84 | MAPT (0.45) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2907292 | 0.83 | NPC1 (0.42) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2906805 | 0.83 | NPC1 (0.46) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2901726 | 0.80 | MAPT (0.46) | HTTSMN1; SMN2TSHRKDM4EMEN1 | |
| SCHEMBL2901736 | 0.80 | L3MBTL1 (0.40) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2904554 | 0.80 | NPC1 (0.37) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2909239 | 0.79 | NPC1 (0.38) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2904287 | 0.79 | L3MBTL1 (0.48) | NPC1RAB9AHTTLMNASMN1; SMN2 | |
| SCHEMBL2907027 | 0.78 | NFKBIA (0.46) | NPC1RAB9AHTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989628-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | claimed |
| US-7989628-B2 | 2-aminoquinolines | HOFFMANN-LA ROCHE INC. (US) | 2011-08-02 | — | — | US | disclosed |