Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 2/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | IDE | P14735 | 1/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453555 | 0.89 | HIF1A (0.44) | SERPINE1HIF1ANPC1ACVRL1EPHX2 | |
| SCHEMBL22452974 | 0.83 | HIF1A (0.53) | SERPINE1HIF1ANPC1ACVRL1AURKA | |
| SCHEMBL22453415 | 0.82 | SERPINE1 (0.53) | SERPINE1HIF1ANPC1AURKAEPHX2 | |
| SCHEMBL22453267 | 0.82 | SERPINE1 (0.42) | SERPINE1HIF1ANPC1AURKAEPHX2 | |
| SCHEMBL22453269 | 0.82 | SERPINE1 (0.42) | SERPINE1HIF1ANPC1ACVRL1EPHX2 | |
| SCHEMBL22452684 | 0.81 | HIF1A (0.52) | SERPINE1HIF1AEPHX2ALDH1A1EPAS1 | |
| SCHEMBL22453641 | 0.81 | DHODH (0.55) | SERPINE1HIF1ANPC1ALDH1A1EPAS1 | |
| SCHEMBL22453312 | 0.81 | SERPINE1 (0.43) | SERPINE1HIF1ANPC1AURKAKMO | |
| SCHEMBL22452560 | 0.80 | SERPINE1 (0.40) | SERPINE1HIF1ANPC1AURKAEPHX2 | |
| SCHEMBL22453230 | 0.80 | SERPINE1 (0.46) | SERPINE1HIF1ANPC1EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |