Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 9/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453640 | 0.95 | DHODH (0.57) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22453002 | 0.94 | DHODH (0.50) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22453315 | 0.93 | DHODH (0.47) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22453313 | 0.92 | DHODH (0.48) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22452804 | 0.91 | SERPINE1 (0.57) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22453117 | 0.89 | CNR2 (0.53) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22453073 | 0.89 | DHODH (0.47) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22452529 | 0.89 | DHODH (0.41) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22453269 | 0.87 | SERPINE1 (0.42) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL22452486 | 0.86 | HIF1A (0.50) | MEN1KMT2ARAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |